Dedifferentiation of Adult Human Myoblasts Induced by Ciliary Neurotrophic Factor In Vitro
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چکیده
منابع مشابه
Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro.
Ciliary neurotrophic factor (CNTF) is primarily known for its important cellular effects within the nervous system. However, recent studies indicate that its receptor can be highly expressed in denervated skeletal muscle. Here, we investigated the direct effect of CNTF on skeletal myoblasts of adult human. Surprisingly, we found that CNTF induced the myogenic lineage-committed myoblasts at a cl...
متن کاملDedifferentiation of Adult Human Myoblasts Induced by CNTF in Vitro
1 Department of neurophysiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China 2 Institute of Space Medical Engineering, 1 YuanmingYuan West Road, Beijing 100094, China 3 Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, China 4 Children’s Hospital of Pittsburgh, 5646 Darlington Road, Pittsbu...
متن کاملCiliary neurotrophic factor receptor regulation of adult forebrain neurogenesis.
Appropriately targeted manipulation of endogenous neural stem progenitor (NSP) cells may contribute to therapies for trauma, stroke, and neurodegenerative disease. A prerequisite to such therapies is a better understanding of the mechanisms regulating adult NSP cells in vivo. Indirect data suggest that endogenous ciliary neurotrophic factor (CNTF) receptor signaling may inhibit neuronal differe...
متن کاملThe trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat
Objective(s): Occlusal trauma is one of the most common forms of oral biting dysfunction. Long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. Through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (CNTF) on injured masseter muscle. Materials and Methods: Male Wistar rats (n=36) were random...
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Neurogenesis continues in the adult forebrain subventricular zone (SVZ) and the dentate gyrus of the hippocampal formation. Degeneration of dopaminergic projections in Parkinson's disease and animals reduces, whereas ciliary neurotrophic factor (CNTF) promotes, neurogenesis. We tested whether the dopaminergic system promotes neurogenesis through CNTF. Astrocytes of the SVZ and dentate gyrus exp...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2005
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e05-03-0218